News
- Category: News
- CARE 6th and final External Newsletter is now available
- Successful CARE Final Annual meeting
- From Crisis to Innovation: How the CARE Consortium has Shaped the Future of Pandemic Response
- Five years on a page – CARE’s final infographic detailing the consortium’s objectives, achievements, outcomes and more
- Published in IJBM: SARS-CoV-2 Mpro oligomerization as a potential target for therapy
- Published in NAR: formation of the SARS-CoV-2 methylation complex
- Published in Virology: a new cell line permissive to human coronavirus 229E
- Published in American Chemical Society Pharmacology & Translational Science: Effective, but Safe? Physiologically Based Pharmacokinetic (PBPK)-Modeling-Based Dosing Study of Molnupiravir for Risk Assessment in Pediatric Subpopulations
- Introducing Scifeon – a CARE SME organisation
- CARE 5th External Newsletter is now available
- CARE – Infographic – Work Package 8 – Management, ethics, communication, dissemination and exploitation: focusing on laboratory and clinical data management
- Collaboration between Dundee DDU and Biomedical Research Unit of Novartis announced, to continue development of an antiviral compound for future coronavirus pandemic preparedness
- Publication in Vaccines: Protection of K18-hACE2 Mice against SARS-CoV-2 Challenge by a Capsid Virus-like Particle-Based Vaccine
- CARE – Infographic – Work Package 7 – Clinical evaluation of repurposed or novel SARS-CoV-2 antivirals or antibodies
- Publication in Antiviral Research: Combining of Remdesivir, Molnupiravir and Ribavirin inhibits coronavirus replication
- The COVID-19 QTL-GWAS colocalization explorer application – allowing easy query of summary statistics and visualization of the genomic context of significant COVID-19 gene links
- A picture paints a thousand words: Utrecht University expertise in Cryo-EM technology continues to bring benefit to CARE’s small molecule and antibody development work
- Published in PLoS Pathogens: picornaviruses modulate nucleotide metabolism
- CARE – Infographic – Work Package 6 – From lead to pre-clinical candidate and proof-of-concept in small-animal and non-human primate models
- Published in MCP: Assessment of Kinome-Wide Activity Remodeling upon Picornavirus Infection
- CARE’s Young Researcher – Oliver Debski-Antoniak
- Published in Nature: First insights into the Porcine Deltacoronavirus spike
- CARE – Infographic – Work Package 5 – identifying immune markers contributing to the host immune responses to SARS-CoV-2 infection and their correlations with clinical and virological outcomes
- CARE’s Young Researcher – Manon Laporte
- CARE – Infographic – Work Package 4 – Generation and characterisation of monoclonal antibodies against SARS-CoV-2 and related coronaviruses
- CARE’s Young Researcher – Holly Kerr
- Introducing NUVISAN – a CARE Industry organisation
- CARE – Infographic – Work Package 3 Antiviral drug development: Hits to Leads
- Published in Antiviral Research: A new fully automated dual-reporter HTS antiviral assay to facilitate drug discovery against SARS-CoV-2
- CARE 4th External Newsletter is now available
- CARE’s Young Researcher -Thijs Steijaert
- CARE – Infographic: Work Package 2 Target-based drug discovery and design
- Published in Viruses: Lower infectivity of recent SARS-CoV-2 omicron sub–variants in Syrian Hamster
- CARE’s Young Researcher – Wenjuan Du
- Published in Viruses: CXCL12 and CXCL13 Cytokine Serum Levels Are Associated with the Magnitude and the Quality of SARS-CoV-2 Humoral Responses
- CARE’s Young Researcher – Collins Owino
- CARE – Infographic: Work Package 1 anti-coronavirusdrug discovery in phenotypic virus-cell-based assays
- CARE – Infographic: Research objectives and operating model
- Published in Antiviral Res: A new image-based and high-throughput platform to identify broad-spectrum coronavirus antivirals
- Introducing Utrecht University – a CARE academic organisation
- CARE Partner perspectives – Frank van Kuppeveld
- CARE – Infographic: Leadership and partnership
- Introducing The Institute of Virology and Immunology (IVI) – a CARE academic organisation
- CARE Partner perspectives – Rob Jordan
- Successful CARE 4th Annual meeting
- CARE convenes for its 4th Annual meeting on March 12-13
- CARE Partner perspectives – Yves Lévy
- CARE Partner perspectives – Cyril Dousson
- CARE – Infographic: What is CARE?
- The faces behind the CARE work-packages – Panthéa Tzourio, WP8 Task Lead
- The faces behind the CARE work-packages – Craig Fenwick, WP4 academic Lead
- The faces behind the CARE work-packages – Richard Zwaal, WP1 EFPIA Lead
- New potent bisubtrate inhibitors of SARS-CoV-2 nsp14 N7-Methyltransferase
- Preparing for future pandemics: outputs and progress resulting from a European Commission sponsored workshop in November 2022
- CARE 3rd External Newsletter is now available
- Published in Journal of infection: a new potent, broad-spectrum antibody isolated
- Introducing Iktos – a CARE SME organisation
- Introducing Ai-biopharma – a CARE SME organisation
- Introducing Leiden University Medical Center – a CARE academic organisation
- Inserm VRI-led research reveals predictors of severe disease and long COVID symptoms
- One new deliverable available on CARE website
- CARE latest annual project summary available
- About CARE’S Scientific and Ethics Advisory Board
- An overview of SCORE – a small EU-funded consortium with many connections to CARE
- CARE’s Young Researcher – Emmely Treffers
- CARE’s Young Researcher – Grace Beirne
- CARE – Committed to the COVID-19 cause
- CARE presentation at 9th ESWI Influenza conference in Valencia
- Published in Frontiers in Medicine: The application of data altruism in clinical research through empirical and legal analysis lenses
- CARE 2nd External Newsletter is now available
- Published in PNAS: A broad-spectrum macrocyclic peptide inhibitor of the SARS-CoV-2 spike protein
- Successful CARE 3rd Annual meeting
- CARE is meeting for its 3rd Annual meeting on June 6-7
- Published in J Clin Immunol: Persistence of abnormalities in the blood of convalescent COVID-19 patients until 6 months after hospital discharge
- Published in Microorganisms: Z-Tyr-Ala-CHN2, a Cathepsin L Inhibitor with Broad-Spectrum Cell-Specific Activity against Coronaviruses
- CARE presentation at at 19th Annual PEGS Boston conference and expo
- Published in Antiviral Res: A VeroE6 cell line not requiring Pgp inhibitors to evaluate SARS-CoV-2 antivirals
- Published in iScience: A new optimized SARS-CoV-2 phenotypic screening platform
- Published in Journal of Virology: A new mouse model for preclinical evaluation of potential antivirals
- Published in Frontiers in Pharmacology: Combination of antiviral drugs proved to be more efficient than monotherapy
- CARE presentation at ICAR2023
- The faces behind the CARE work-packages – WP7
- FAIRplus and CARE collaboration to publish FAIR SARS-CoV-2 data
- Iktos, a new CARE partner
- Follow us on LinkedIn!
- Published in Frontiers in Medicine: the COVID-19 pandemic hampered the sharing of information with and securing of consent from clinical study participants, but did not impact GDPR compliance
- Published in Structure: An insight into nsp10-mediated modulation of nsp14 exonuclease activity
- Published in Nature Micobiology: a new monoclonal antibody neutralizing SARS-CoV-2 Omicron variants
- CARE 1st External Newsletter is now available
- Call for collaboration
- Five new deliverables are now publicly available on CARE webpage “Resources”!
- The faces behind the CARE work-packages – WP6
- The faces behind the CARE work-packages – WP5
- The faces behind the CARE work-packages – WP4
- Published in eBioMedicine: Design, immunogenicity, and efficacy of a pan-sarbecovirus dendritic-cell targeting vaccine
- Published in JAMA Oncology: Humoral Responses Against Variants of Concern by COVID-19 mRNA Vaccines in Immunocompromised Patients
- Published in MDPI: Synthesis, Structure-Activity Relationships, and Antiviral Profiling of 1-Heteroaryl-2-Alkoxyphenyl Analogs as Inhibitors of SARS-CoV-2 Replication
- Published in CellPress iScience: Computed Tomography and [18 F]-FDG PET imaging provide additional readouts for COVID-19 pathogenesis and therapies evaluation in non-human primates
- CARE 2nd Annual meeting
- CARE paper published in Antiviral Research: Insight on the activity of Remdesivir, Molnupiravir and Nirmatrelvir on SARS-CoV-2 variants of concern
- CARE paper published in Journal of Medical Virology: Development and optimization of a high-throughput screening assay for in vitro anti-SARS-CoV-2 activity
- White paper published: High throughput cryo-electron microscopy epitope mapping of SARS-CoV-2 spike protein antibodies
- Published in Nature Communications: Mechanism of AT-527 presents as a promising research avenue against COVID-19
- The faces behind the CARE work-packages – WP3
- The faces behind the CARE work-packages – WP2
- The faces behind the CARE work-packages – WP1
- CARE paper published in JCIM: Modeling of protein-small molecule complexes with HADDOCK
- CARE paper published in Journal of Virology: New insights for assessment of SARS-CoV-2 infection estimates and (vaccine-induced) antibody durability response
- CARE paper published in Science Translational Medicine: New cell-free assay
- CARE paper published in Circulation: Mechanisms of SARS-CoV-2 with regards to endothelial cells
- CARE paper published in iScience: CD177 is associated with coronavirus disease 2019 severity and death
- CARE paper published in Nature: HCQ use against SARS-CoV-2 infection
- Repurposing efforts concluded
- CARE scientists identified a SARS-CoV-2 neutralizing antibody with activity against all known variants of concern
- One Year of CARE Against COVID-19
- One Year of CARE Against COVID-19
- One Year of CARE Against COVID-19
- Survey on GDPR and eConsent during the COVID-19 pandemic
- Mention of CARE in Le Monde
- EMA – ITF collaboration
- IMI Press release
- CARE Press release
- CARE Kick-off meeting week
- Start of the CARE project